Phosphofructokinase deficiency is an inherited glycogen storage disease. Without the enzyme phosphofructokinase, muscle cells and red blood cells are not able to produce enough energy to meet their needs. Clinical signs are weakness, lethargy, exercise intolerance and anaemia.

Transmission

Autosomal recessive

Breed

American cocker spaniel, English Cocker Spaniel, English Springer Spaniel, Whippet