Dog

Each dog has its own DNA signature. It is a sort of genetic identity card containing 22 microsatellites recommended by the International Society for Animal Genetics (ISAG). Progenus is accredited ISO17025 for this test.

Retinal Dysplasia with Osteoskeletal Dysplasia (OSD1) is a genetic disease that affects collagen in Labrador Retrievers. It manifests itself as dwarfism with short limbs, especially the front legs, as well as ocular abnormalities such as retinal detachment and cataracts.

Affected dogs show signs as early as 4 to 6 weeks of age, with shortened and deformed front legs, a sometimes bulging skull and slightly squinty eyes. Eye lesions include retinal detachment and cataracts, while bone growth plates are poorly organised.

The disease is caused by a mutation that prevents the correct production of collagen, affecting the eyes more severely than the bones. Carriers of the mutation generally do not have bone problems, but may have mild eye damage.

Neurodegenerative vacuolar storage disease, also known as cerebellar ataxia, is a genetic disorder caused by the accumulation of non-eliminated substances in the lysosomes of nerve cells.

Affected dogs show symptoms such as progressive loss of movement coordination (ataxia), abnormal eye movements, and behavioral disorders (agitation, depression, aggression). Although reflexes may appear normal, neurological examinations often reveal atrophy of the cerebellum.

The disease is autosomal recessive, meaning that only dogs carrying two copies of the mutated gene show symptoms, usually around 23 months of age, but onset can vary.

Neuroaxonal dystrophy (NAD) is a group of inherited neurodegenerative diseases characterised by the presence of spheroids (swollen axons) in the central nervous system. In Miniature American Shepherds, this disease manifests itself as a progressive weakening of the hind limbs, an unsteady gait and coordination problems (ataxia). Affected dogs often show these symptoms from young adulthood, leading to increasing difficulty in moving around. NAD can progress slowly, and although the disease is not immediately fatal, it can seriously affect the quality of life of affected dogs, sometimes leading to euthanasia due to the severity of the symptoms.

Complement factor C3 deficiency in dogs is a condition that leads to immune system failure. This condition makes affected dogs more susceptible to multiple and recurrent bacterial infections, as well as certain kidney diseases of immune origin. The gene involved in this pathology is the C3 gene, with a specific mutation identified as c.2136delC. The frequency of carriers of this mutation is approximately 1%, and symptoms can appear from a very young age.

This panel includes the specific tests to be performed for the Romagnol Water Dog: Benign familial juvenile epilepsy (DOG-BFJE), Progressive rod-cone degeneration (DOG-PRA-PRCD), Hyperuricosuria (DOG-HUU) and Neurodegenerative vacuolar storage disease (DOG-LSD).

This panel includes the specific tests to be performed for the Black Russian Terrier: hyperuricosuria (DOG-HUU) and Juvenile Laryngeal Paralysis and Polyneuropathy (DOG-JLPPTNR)

This panel includes the specific tests to be performed for Staffordshire Bull Terriers: cataract (DOG-HSF4-T) and L2 hydroxiglutaric aciduria (DOG- L-2-HGA).

This panel includes the specific tests to be performed for the Golden Retriever: Dystrophic epidermolysis bullosa (DOG-DEB), muscular dystrophy (DOG-GRMD), Ichtyosis (DOG-ICHGR), Neuronal ceroid lipofuscinosis type 5 (DOG-NCL5GR), osteogenesis imperfecta (DOG-OSTEO-GR), progressive retinal atrophy (DOG-PRA1-GR) and progressive rod-cone degeneration (DOG-PRA-PRCD).