Dog

Malignant hyperthermia, also known as canine stress syndrome, is a potentially fatal genetic disorder. The clinical signs of malignant hyperthermia are extreme muscle contractions, increased heart rate and fever. These symptoms are triggered by certain anaesthetics such as halothane, but also by intense exercise and certain foods. Malignant hyperthermia can be tested for in any breed, but is most commonly found in the breeds listed below.

Intervertebral disc disease is a premature abnormal degeneration of the intervertebral discs. In chondrodystrophic breeds, premature calcification of the nucleus pulposus causes disc degeneration in young dogs. These abnormal discs are prone to herniation into the spinal canal where inflammation and bleeding can cause severe pain and neurological dysfunction called intervertebral disc disease. This condition can lead to the death of the animal. IVDD can be tested for in any breed, but is most commonly found in the breeds listed below.

Progressive rod-cone degeneration is one of several forms of progressive retinal atrophy (PRA), which causes the degeneration and death of retinal cells. The main symptom is progressive vision loss from the age of 3-5 years. The test can be performed for any breed, but is particularly relevant for the breeds listed below

Cone-rod dystrophy 1 is a form of progressive retinal atrophy characterised by an early, severe and rapidly progressive loss of cone function accompanied by a progressive loss of rods.

Cone-rod dystrophy 2 is a form of progressive retinal atrophy characterised by an early, severe and rapidly progressive loss of cone function accompanied by a progressive loss of rods.

Progressive retinal atrophy 4, also known as CORD1, is a form of progressive retinal atrophy characterised by changes in the granular appearance of the fundus, followed by generalised tapetal hyperreflexia and retinal vascular attenuation with progressive extinction of the electroretinogram. CORD1 pathology is probably caused by a combination of mutations. Only the mutation in the RPGRIP1 gene is being tested.

Progressive retinal atrophy is an inherited eye disease characterised by bilateral degeneration of the photoreceptor cells of the retina resulting in progressive vision loss leading to total blindness. Other mutations can cause progressive retinal atrophy. PRA1 accounts for more than 60% of diagnosed Golden Retrievers.

Progressive retinal atrophy 1 is one of several forms of progressive retinal atrophy (PRA). The degeneration of the photoreceptors leads to blindness before the age of two.

Rod-cone dysplasia 4 is one of several forms of progressive retinal atrophy (PRA). This mutation leads to the late onset of PRA, with blindness occurring after 7 years of age.

Multifocal retinopathy is an eye disease with symptoms appearing between 11 and 16 weeks of age. Affected dogs have multiple circular areas of retinal detachment. Fluid accumulates under the detached retina, resulting in blistering of the eye. The disease progresses slowly and does not usually lead to blindness.