Dog

Spinocerebellar ataxia (LOA) is a genetic disease of the nervous system. Affected dogs present the first signs of ataxia around the age of 6 to 12 months. The symptoms of this pathology are a loss of balance, a progressive lack of coordination until the total loss of mobility. nother test for spinocerebellar ataxia is available. For more information, consult the DOG-SCA test.

Polyneuropathy type 1 (LNP1) is a progressive neuromuscular disease characterised by generalised weakness, hypotonia, laryngeal paralysis and muscle atrophy, particularly of the hind limbs. The age of onset of symptoms can vary between 1 and 11 years.

Von Willebrand disease is a disease that causes excessive bleeding due to a lack or reduced level of von Willebrand factor (vWF), a blood clotting protein. This disease is inherited as a dominant trait with incomplete penetrance, which means that not all dogs carrying the vWF mutation will show clinical signs of the disease.

Polyneuropathy type 1 (LNP21) is a progressive neuromuscular disease characterised by generalised weakness, hypotonia, laryngeal paralysis and muscle atrophy, particularly of the hind limbs. The age of onset of symptoms can vary between 1 and 11 years.

Von Willebrand disease is a condition that causes excessive bleeding due to a lack or reduced level of von Willebrand factor (vWF), a blood clotting protein. 

Laryngeal paralysis and polyneuropathy (LPPN3) is a disease characterised by breathing difficulties, often described as noisy or hoarse breathing. Other clinical signs, which vary from dog to dog, include difficulty swallowing, changes in frequency and quality of barking, high gait, lack of muscle coordination, exercise intolerance and muscle atrophy of the limbs.

Trapped neutrophil syndrome is an immune system disorder. Affected puppies suffer from chronic infections and developmental delays.

Hypomyelination, also known as Shaking pup syndrome, is a disorder of the nervous system caused by a defect in the myelination of the spinal cord. Affected dogs show tremors, walking difficulties, balance and coordination problems. This disease is transmitted in an X-linked recessive manner, so males carrying the mutation will all be affected. However, only females with 2 copies of the mutated allele will be affected.

Skeletal Dysplasia 2 (SD2) is a genetic disorder causing mild disproportionate dwarfism. Affected dogs have short legs with normal proportions for the rest of the body. This mutation has incomplete penetrance: not all dogs with two copies of the defective gene will show signs of skeletal dysplasia.

Spongy degeneration with cerebellar ataxia 1 is a neurodegenerative disorder of the cerebellum. Affected puppies show ataxia with motor disorders, muscle spasms and loss of balance. Following the progression of symptoms, puppies are usually euthanised before 4 months of age.