Locus S identifies piebald/white spotting patterns in dogs. A particular mutation within the MITF gene is linked to piebald spotting, though its impact varies across breeds. In breeds such as Collies and Boxers, this mutation exhibits dosage-dependent effects, where one copy produces partial white patterns and two copies result in more extensive white. Conversely, in other breeds, piebald spotting follows a recessive pattern, necessitating two copies for manifestation.
Transmission
Autosomal recessive or incomplete dominance depending on the breed
